Monthly Archives: May 2017

Whole-cell patch clamp, part 3: Limitations of quantitative whole-cell voltage clamp

Before I first dived into experimental neuroscience, I imagined whole-cell voltage clamp recordings to be the holy grail of precision. Directly listening to the currents that take place inside of a living neuron! How beautiful and precise, compared to poor-resolution techniques like fMRI or … Continue reading

Posted in Data analysis, electrophysiology, Neuronal activity, zebrafish | Tagged , , | 3 Comments

Whole-cell patch clamp, part 2: Line-frequency pick-up via the perfusion system

With the experience of more than one year of patching (although you might say that this is not a lot), I’m now used to problems that I can solve after some time, but without being able to tell what the problem has … Continue reading

Posted in electrophysiology, Microscopy | Tagged | 1 Comment